We have checkpoint on our remote clients and connect to them through PCA when connected to checkpoint VPN. A lot of the times we need to restart the PCA service to be able to connect. Any reason for this ?

Does this help

pcAnywhere host stops working after a VPN connection is established

A permanent fix to resolve the behavior described above is to set the value of TCPIPHostBindMode to 0 on the affected computers.  Continue reading for more details...

The following registry key controls the behavior of the Symantec pcAnywhere Host Service with respect to how it binds to available network interfaces:
Key: HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\pcANYWHERE\CurrentVersion\System
Type: DWORD
Settings:
0 = Bind to default network adapter
1 = Bind to every network adapter
2 = Bind to specific network adapter defined by TCPIPHostAddressIndex

For the Symantec pcA agent, the default values are:
TCPIPHostBindMode = 1
TCPIPHostAddressIndex = 0

Set TCPIPHostBindMode to 0, rather than its default value of 1, to resolve this issue.  It is not necessary to make these changes for all VPN client software.  Therefore, Symantec has no plans to change the default values.

ref:

http://www.symantec.com/docs/TECH138227