Does anything with SEPM need to be changed when switching the domain the windows 2008 server is on?
Nothing needs to be done;
Make sure the version compatible with 2008 is MR5 or greater version
good to have backup incase something goes wrong
Thanks!
Good to have this link handy
http://service1.symantec.com/support/ent-security.nsf/854fa02b4f5013678825731a007d06af/a0edb796f583c886882574aa004c1f60?OpenDocument