Hi Salim,
if you asking about monitoring the execution of exe (binary files ) then you can use application monitoring feature of DLP which can monitor and block.
Application monitoring lets you monitor third-party applications for IM, email, or HTTP/S clients. By default, Symantec Data Loss Prevention only monitors first-party applications such as AIM, Microsoft Outlook, or Mozilla Firefox. Examples of third-party applications include Skype, Mozilla Thunderbird, or Google Chrome. Any application that is not specifically monitored by Symantec Data Loss Prevention must be added to the Application Monitoring page before Symantec Data Loss Prevention can begin monitoring.
Also if you asking about transderring of binary files the you need IDM technology to implement throgh the hasing such kind of data.
Also please refer below
https://www-secure.symantec.com/connect/forums/dlp-skype-support#comment-8051291
https://www-secure.symantec.com/connect/forums/how-create-script-custom-file-type-detection-symatnec-data-loss-prevention-dlp
https://www-secure.symantec.com/connect/forums/detection-customization-file-analyzer