Hello,
Could you please PM me your Case #?
I hope all the GUP client machines are not Windows XP machines.
From where does the GUP take update (SEPM / LUA)?
By default (As per Microsoft), Windows XP has a maximum limit of 10 inbound concurrent connections and for Windows 7 it is 20 inbound concurrent connections.
Are the GUP clients are of the same version as of SEPM?
Check these Articles:
Group Update Provider is not updating all the clients
http://www.symantec.com/docs/TECH140798
Please test the Connection between SEPM <<>> GUP <<>> Clients.
http://www.symantec.com/docs/TECH153328
Also, check the SEP Content Distribution Monitor (for GUP health-checking)
https://www-secure.symantec.com/connect/downloads/sep-content-distribution-monitor
SEP Content Distribution Monitor - Introduction
https://www-secure.symantec.com/connect/videos/sep-content-distribution-monitor-introduction
Hope that helps!!