1. how many such GUPs ?
2. Are clients and GUPs in same subnet?
3. Is GUP downloading Delta Definitions ?
4. From a client machine can you telnet port 2967 ?
5. What is the version of SEP clients and GUP ?
6. Is GUP client working properly (Disk Space, SMC service restarted etc)
I guess one of these questions will also answer your basic question