The Log.LiveUpdate file shows the following errors (snippet):
Unknown function name GetSiloID was used
PreCondition evaluation aborted with error code 5
Aborted patch with EES code: LU1849; Product: SEPM Iron Settings v12.1
In the SEPM under Admin -> Servers -> Local Site you see the following entry in the mini log section on the bottom-right. This mini log only shows the last 10 Server Activity entries.
Symantec Endpoint Protection Manager could not update Centralized Reputation Settings 12.1 <RU version>.
You can view a more expansive list of the SEPM logs by going to Monitors -> Logs and selecting Log Type: "System" and Log Content: "Server Activity" and hitting the View Log button. Here you'll see the same error as listed above.