Hello,
Here is the Documentation on the W32.Downadup (Symantec) aka Conficker (Microsoft)
Best Practice for Downadup.B and Additional information on the same.
https://www-secure.symantec.com/connect/articles/best-practice-downadupb-and-additional-information-same
Downadup (conficker) is quite old virus. If all machines are patched and udpated with the newest virus definitions you should be safe. However, there are few things to be verified. This is well described in the following document:
Simple steps to protect yourself from the Conficker Worm
http://service1.symantec.com/support/ent-security.nsf/docid/2009033012483648
Work on the Plan of Action as given below for a 100% result.
Plan of Action:
1) Make sure ALL Computers are installed with Symantec EP with latest / updated with virus defintions and
2) Install MS08-67 patch download [KB 958644] on ALL computer.
http://www.microsoft.com/technet/security/Bulletin/MS08-067.mspx
3) Install ALL Latest Microsoft Secuirty Patches / Sevice Packs on ALL machines
4) Disable Auto play with GPO
http://support.microsoft.com/kb/953252
5) Disable Scheduled Tasks with GPO
http://support.microsoft.com/kb/310208
6) Enable Security Auditing with GPO
http://support.microsoft.com/kb/300549
7) Scan ALL the machines...
8) Enable Risk Tracer
http://service1.symantec.com/support/ent-security.nsf/854fa02b4f5013678825731a007d06af/be1edccb0e39927280257363003a2bb3?OpenDocument
Incase, we don't have Network Threat Protection Installed on Machines, then we could try NMAP (http://insecure.org/)
NOTE: NMAP is not Supported by Symantec. However, have proved to be effective.
NOTE: *ALL means ALL client machines and server machines (make sure you don't miss any machine)
Similar Threads:
https://www-secure.symantec.com/connect/forums/w32downadupb-how-could-you-find-source-if-there-are-1k-infected
https://www-secure.symantec.com/connect/forums/w32downadupb-5
https://www-secure.symantec.com/connect/forums/account-lockdown-pertaining-domain-controller
Hope that helps!!