Is there a document that someone can point me to that details best practices for setting up SQL servers in multiple data centers in a large SEP environment

configuring SQL should be in accordance with Microsoft recommendation. For exclusion of MS SQL on SEP installed client, you can check this URL

http://www.symantec.com/business/support/index?page=content&id=TECH105240

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Best Practices for Installing Symantec Endpoint Protection (SEP) on Windows Servers

How to exclude MS SQL files and folders using Centralized Exceptions

Hello,

Check these Articles:

Best Practices guide for Installing the Symantec Endpoint Protection Manager with a SQL Server 2005 Database
http://www.symantec.com/docs/TECH104405 

Best Practices guide for Installing the Symantec Endpoint Protection Manager 11 RU5 with a SQL Server 2008 Database
http://www.symantec.com/docs/TECH96451 

Microsoft SQL Server requirements for Symantec Endpoint Security 11.0 and Symantec Network Access Control 11.0

http://service1.symantec.com/SUPPORT/ent-security.nsf/2326c6a13572aeb788257363002b62aa/216db2f2828c1274ca25737b0040d3e5?OpenDocument

Hope that helps!!